⚠️ Medications That May Harm Brain Function
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Proton Pump Inhibitors (PPIs)
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Example: Omeprazole, Lansoprazole
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Risk: Linked to cognitive decline with prolonged use.
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Why: May affect nutrient absorption (e.g. B12), vital for brain health.
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Anticholinergics
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Used for: Parkinson’s, overactive bladder
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Risk: Block acetylcholine, increasing dementia risk by up to 54%.
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Includes some sleep aids and older antihistamines like diphenhydramine.
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Corticosteroids
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Used for: Inflammation, autoimmune disorders
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Risk: Long-term use may cause confusion, anxiety, depression, and raise dementia risk.
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Benzodiazepines
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Example: Diazepam, Alprazolam
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Risk: Memory problems, dependence, and higher risk of Alzheimer’s with prolonged use.
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Amphetamines
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Used for: ADHD
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Risk: Potential for memory loss and long-term cognitive effects with chronic use.
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First-Generation Antihistamines
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Example: Diphenhydramine
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Risk: Anticholinergic properties linked to memory decline.
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Alternative: Second-generation options like cetirizine are safer for long-term use.
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Tricyclic Antidepressants
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Example: Amitriptyline
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Risk: Anticholinergic side effects contribute to cognitive issues, especially in older adults.
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Statins
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Example: Simvastatin
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Risk: Mixed evidence — some report memory problems, others show potential dementia protection.
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